Department of Biomedical Sciences, University of Cagliari, Monserrato, CA, 09042, Italy. melaniamelis@unica.it. Department of Biomedical Sciences, University of Sassari, Sassari, SS, 07100, Italy. Department of Biomedical Sciences, University of Cagliari, Monserrato, CA, 09042, Italy. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, SS, 07100, Italy. Sardinia Longevity Blue Zone Observatory, Ogliastra, Italy.